PROGRAM
WEDNESDAY July 24th
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Introduction of the course
(Dr. I. Castellano, Prof. A. Merlino)
Morning (09.30-12.30)
Welcome to students and little Introduction to the course
Theoretic Lecture :
Protein structure, protein folding and adaptation to different environments.
Coffee Break
Protein structure: experimental determination and analysis.
Afternoon (15.00-18.00)
Practical session:
Protein Data Bank and molecular graphics.
THURSDAY, July 25th
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Protein Evolution
(Dr. M. Gerdol)
Morning (09.30-12.30)
Theoretic Lecture :
Origin of primordial proteins, evolutionary divergence (and convergence) of proteins, evolution of protein complexity (protein families).
Coffee Break
Selection of functional mutations, examples of protein evolution, constrains that structure exerts on function and evolution of proteins.
Afternoon (15.00-18.00)
Practical session:
Phylogenetic reconstruction approaches, statistical models for the study of protein evolution.
(20.00)
Social Dinner
FRIDAY July 26th
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Protein interactions
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(Dr. A. Facchiano)
Morning (09.30-12.30)
Theoretic Lecture:
Protein function: ligand interaction, small molecules and large molecules.
Coffee break
Molecular simulations: protein modelling and protein-docking simulations.
Afternoon (15.00-18.00)
Practical session:
Simulation of protein-ligand interaction by docking tools.